Clinical Studies of COMET for Total LSCD: a Review of the Methods and Molecular Markers for Follow-Up Characterizations

This review outlines the main features of clinical trials where cultivated oral mucosa epithelial cell transplantation (COMET) was performed, aiming to underscore a link between outcome and expression specific markers during follow-up patients, characteristic for defined epithelium (cornea, mucosa, or conjunctiva) related vascularization. Currently, little is known about reasons underlying success failure COMET. To address this issue, we focused on tissue characterization at molecular level, highlighting findings concerning angiogenesis. There are several discrepancies in outcomes COMET trials. While some corneal/conjunctival can be considered reliable understanding biological mechanisms that drive corneal repair after transplants, unique marker specifically expressed an accurate study vascularization processes currently missing. Together, these insights will help forecast successes failures technologies.